The risk or severity of bleeding and bleeding was increased when salicylamide was used with acenocoumarol.

Protein binding of Acetohexamide is reduced when co-administered with salicylamide.

Salicylamide may decrease the rate of excretion of aclidinium, resulting in higher serum levels.

Salicylamide may decrease the rate of excretion of Acrivastine, resulting in higher serum levels.

The risk or severity of nephrotoxicity is increased when acyclovir is used in combination with salicylamide.

The salicylamide and 2-hydroxyisophthalamide moieties are also good complexing groups for trivalent lanthanide ions and are also good chromophores. These functions can be introduced into podand or cryptand (Figure 12). The resulting ligands result in highly stable complexes, especially at physiological pH, as the hydroxyl protons have a pKa of approximately 6–6.5.

Niclosamide, a derivative of salicylamide, is an effective anthelmintic. Its actions include inhibition of mitochondrial oxidative phosphorylation in mammals and parasites. It simultaneously inhibits the uptake of glucose and oxygen by the parasite. At therapeutic doses, it has little pharmacological effect on the host organism.

Similarly, benzoxazolones are formed from the Curtius rearrangement of the azide of salicylic acid or o-hydroxyphenyl isocyanate generated by the action of sodium hypochlorite on salicylamide.