New therapeutic alternatives for pain relief include the use of phosphodiesterase-5 (PDE5) inhibitors, which could prevent the transmission of painful stimuli by neuron hyperpolarization via nitric oxide (NO)/cyclic 3',5'-guanosine monophosphate (cGMP) pathway. selleck chemicals The present work investigated the antinociceptive activity of a new PDE5 inhibitor, lodenafil carbonate, in...