T cell engineering with antigen-specific T cell receptors (TCRs) has allowed the generation of increasingly specific, reliable, and versatile T cell products with near-physiological features. However, a broad applicability of TCR-based therapies in cancer is still limited by the restricted number of TCRs, often also of suboptimal potency, available for clinical use. In addition, targeting of...
Recent years have seen a growing interest in the development of non-invasive devices capable of detecting seizures which can be worn in everyday life. Such devices must be lightweight and unobtrusive which severely limit their on-board computing power and battery life. In this paper, we propose a novel technique based on hyperdimensional (HD) computing to detect epileptic seizures from...
The improved particle swarm optimization algorithm is integrated with variational mode decomposition (VMD) to extract the efficient band-limited intrinsic mode function (BLIMF) of the single and combined power quality events (PQEs). The selected BLIMF of the robust VMD (RVMD) and the privileged Fourier magnitude spectrum (FMS) information are fed to the proposed reduced deep convolutional...
Cell transplantation has come to the forefront of regenerative medicine alongside the discovery and application of stem cells in both research and clinical settings. There are several types of stem cells currently being used for pre-clinical regenerative therapies, each with unique characteristics, benefits and limitations. This brief review will focus on recent basic science advancements made...
e outcomes of ageing patients. The primary aim was to describe the effects for nursing home residents of monthly professional cleaning and individual oral hygiene instruction provided by registered dental hygienists (RDHs), in comparison with daily oral care as usual. The secondary aim was to study the knowledge and attitudes among nursing staff regarding oral health care and needs. In this...
Molecular tumor boards (MTBs) provide rational, genomics-driven, patient-tailored treatment recommendations. Worldwide, MTBs differ in terms of scope, composition, methods, and recommendations. This study aimed to assess differences in methods and agreement in treatment recommendations among MTBs from tertiary cancer referral centers in The Netherlands. MTBs from all tertiary cancer referral...
121) and between the "Electronic Social Networking integration" subscale's score and PCS12 ( = 0.184), with < 0.05. This is the first study to report the results of the translation and validation of the CIQ-R in Italian. The CIQ-R is an important tool for Italian professionals and can be useful in both clinical practice and research for measuring the level of community integration...
The combination of synergized PTT-immunotherapy with other therapeutic strategies is also discussed.Self-assembly of cellulose nanocrystals (CNCs) doped with anisotropic gold nanorods (AuNRs) was studied by small-angle neutron scattering. buy WAY-100635 Correlation distances and structured domains were analysed to determine the influence of CNC and AuNR concentration on structuring. The...
1g, the less frequent head-to-head collisions (n = 6) resulted in a maximum of 113.5g. The results of this study improve the understanding of head impact exposure in youth female soccer players and inform head impact exposure reduction in youth soccer.The coupling between the residual limb and the lower-limb prosthesis is not rigid. As a result, external loading produces movement between the...
An outbreak of coronavirus disease 2019 (Covid-19) occurred on the U.S.S. , a nuclear-powered aircraft carrier with a crew of 4779 personnel. We obtained clinical and demographic data for all crew members, including results of testing by real-time reverse-transcriptase polymerase chain reaction (rRT-PCR). All crew members were followed up for a minimum of 10 weeks, regardless of test results...