At the moment, significant progress has been made in SARS-CoV-2 research. According to research, SARS-CoV-2 primarily uses ACE2 as a receptor for cellular entry, and this process is dependent on TMPRSS2 protease activity and cathepsin B/L activity as a substitute. We present single-cell RNA sequence (scRNA-seq) data to characterize the gene expression changes in various tissues and cells from COVID-19 patients. We can then speculate on the possible genes involved in virus entry and determine which cell types are more vulnerable to SARS-CoV-2 infection.

Emerging single-cell epigenomic methods, particularly high-throughput single-cell assays for transposase-accessible chromatin sequencing (ATAC-seq), have transformed our understanding of gene regulation. Single-cell ATAC-seq can help us understand ACE2 sequence variation and changes in cell subtype proportions in organs between species. We can advance single cell for COVID-19 research by selecting the best-fit animal model based on ATAC-seq data analyses.