Needle-free injection is the use of a high-pressure jet principle to allow liquid or powdered drugs to enter the body tissue by spraying without the aid of a needle during drug injection. The needle-free injection produces a very high jet flow of 150 to 300 m/s. The depth of the piercing body is limited, and the nerve endings are slightly irritated, so there is no obvious tingling sensation when using a needle syringe. The drug solution is dispersed under the skin, the onset time is faster, and the drug absorption rate is higher.

Therefore, in recent years, needle-free injection technology has gradually developed. Needle-free injection has been applied in local anaesthesia, hyperhidrosis, pathological scar, condyloma acuminata, psoriasis and immunotherapy in dermatology. The application of needle-free injection in the field of skin injection and beauty is worthy of research and promotion.

There are two types depending on the dosage form to be administered:

The liquid type is a method in which a liquid medicine is ejected from a spray hole to form a spray liquid, which penetrates into the subcutaneous or muscle layer to exert a drug effect, and is mechanically injected and high-pressure gas-powered.

The mechanical power injection volume is generally 0.01-1 ml, and a solvent having a small viscosity coefficient, strong solvency, strong activity, and good storage stability, such as sterile water for injection, is selected.

The difference between high pressure gas powered injection and mechanical injection is that the injection volume should not exceed 1.5 ml, such as interferon, antibiotics, influenza vaccine, low molecular weight heparin, hepatitis B vaccine, insulin, morphine, lidocaine, erythropoietin and growth hormone. And other drugs.

The powder type is a gas jet that accelerates the powdered drug to a certain speed and penetrates the outer barrier of the skin to be delivered to the subcutaneous, intradermal, mucosal, muscle, and even cells.

It can be divided into spring-compressed powder needle-free injection system and high-pressure gas jet powder needle-free injection system. The applicable drugs are mainly high-activity and low-dose drugs, such as protein-peptide drugs, gene drugs, chemicals and Genetic vaccine.

Problems and limitations of needle-free injection: Small dose:

The conventional needle-free injection has a dosing volume of 0.1-1.0 ml, and 1.5 ml is the upper limit of administration of the needle-free injection. The dosage of needle-free powder injection should be controlled within 6 mg. At the current state of the art, needle-free injection is only suitable for drugs with high solubility and low dose.

Power system defects:

At present, needle-free syringe products on the market mostly use spring or high-pressure gas as the power source. The stability of spring power is poor, which may lead to differences in dosage, which affects the safety and effectiveness of clinical treatment. High-pressure gas power is easy to produce. Great blasting noise.

 

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