This form of magnesium may have potential brain-related benefits and may be used to treat certain brain disorders such as age-related memory loss and depression.

Magnesium l-threonate has only been around since 2010, so it hasn't been used that long—but it's been studied a lot. Studies have shown that it improves short- and long-term memory performance and enhances learning in aged rats. Some preclinical studies have also shown that treatment with the magnesium threonate (MgT) compound can:


Inhibits amyloid plaque formation, reduces inflammation and improves cognition in a mouse model of Alzheimer's disease

increase synapse density

Increased and enhanced production of new neurons in young and old mice

Alleviating the Psychological and Cognitive Effects of Traumatic Brain Injury

Very few magnesium supplements contain magnesium l-threonate, so if you're looking for this particular type of brain benefit, read product labels carefully. Magnesium l-threonate is available in generic form, but Neurocentria is still working on the development and launch of its branded oral compound, MMFS-01.



The recommended dietary intake of elemental magnesium is approximately 400 to 420 mg for men and 310 to 360 mg for women - however, 2000 mg of magnesium L-threonate contains only 144 mg of elemental magnesium.

While magnesium l-threonate is useful as a brain supplement, it may not be ideal as a primary magnesium supplement.