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enclomiphene 50

(Androxal), in development by Repros Therapeutics Inc, is a non-steroidal estrogen

receptor antagonist that promotes gonadotropin-dependent testosterone secretion by

the testes. Enclomiphene constitutes the trans-stereoisomer of clomiphene citrate,

a drug that has been widely prescribed for several decades for the treatment of

female ovulatory dysfunction.


In clinical trials conducted to date,

enclomiphene tablets demonstrated significant efficacy in the physiological restoration of

testosterone levels in males with secondary hypogonadism. The compound also

exhibited an unanticipated favorable effect on fasting plasma glucose; this result

has been accompanied by rapidly accumulating evidence from other researchers for a

bidirectional relationship between low serum testosterone and obesity/metabolic

syndrome (syndrome X) in men.