What do females desire?

According to a 2014 Allergan poll, 75% of women between the ages of 18 and 65 prefer eyelashes that are longer, thicker, and darker. Allergen's blockbuster lash growth serum Latisse, which demonstrates clinically significant increases to lash length, thickness, and blackness after 16 weeks of treatment, was brought to market as a result of this sort of overwhelming demand from market research.

Latisse may have negative effects, which are widely known. Bimatoprost has a prostaglandin analogue as its major active ingredient. Prostaglandins are chemical substances that occur naturally in practically every tissue in our bodies and are in charge of signalling inflammation.

Bimatoprost is also active ingredient of careprost eye drops. The fact that Latisse has been link to typical signs of inflammation around the eyes, such as swollen lids (also known as chemosis), redness, itching, and watering, is thus not surprising.

According to FDA clinical tests, 4% of Latisse users report itchiness, redness, and watering, while a considerably smaller percentage have an allergic response that causes their eyelids to enlarge. In addition to causing chronic itchiness,

Latisse has also been report to darken the iris and skin of the eyelids in individuals with light brown or hazel eyes. It has also been suggest that Latisse may result in a sunken eye appearance by reducing the layers of orbital fat surrounding the eye socket.

It's easy to dismiss eye discomfort as unimportant, but ocular surface dysfunction and chronic dry eye may have a lasting negative impact on the clarity of your vision and the comfort of your eyes.

Studies have shown that prostaglandin analogues, which have been use for decades to treat glaucoma, are substantially associate with persistent dry eye problems. In actuality, clinically significant chronic dry eye illness is diagnose in slightly under 50% of all glaucoma patients using prostaglandin analogue eye drops.

While previously preservatives in drugs like Latisse or glaucoma drops have been held responsible for the majority of dry eye cases, we now know that prostaglandin mimics on their own may result in serious dry eye illness.

Prostaglandin analogues may impair tear film expression and generation by causing inflammation on the ocular surface. This comprises the mucin layer produce by the goblet cells on the conjunctiva's surface and the water layer of our tear film produce by the lacrimal gland.

Sebaceous glands in our eyelids produce oil secretions (sebum) that are thicken as a result of inflammation.

The top coat oils that hold the water and mucin layers of our tear film onto the surface of the eye are secrete by the meibomian (sebaceous) glands that run vertically through our top and bottom eyelids.

The meibomian glands release their oil with each blink. If the oil is excessively thick, the eyelids will struggle to distribute it uniformly throughout the eye's surface, spreading it more like toothpaste than olive oil.

Even worse, the oil may get so thick that it plugs and builds up within the gland. This will gradually but irreparably harm the gland. The body is unable to heal the tissue when the meibomian glands atrophy or die off, leaving the gland permanently inactive.

The end effect is an often very painful and irreparable dry eye. A startling 91.7 percent of patients treat for glaucoma with prostaglandin analogue drops had meibomian gland illness.

A according to a 2015 research, compare to just 57.7 percent of those receiving treatment for glaucoma with a different class of medicine. The careprost is also used for treat glaucoma.

The expense of using Latisse or other prostaglandin analogue drugs has receive more attention in the media than the potential danger of long-term, irreversible dryness and ocular surface damage.

The cost of prescription lash growth is around $130 per month. Due to this price point, over-the-counter alternatives have become more and more popular, but regrettably, some people mistakenly believe that since they are not prescription drugs, they must therefore be safer.

Isopropyl cloprostenate: What is it?

It is a synthetic counterpart of prostaglandin. The same possible side effect profile exists as a result, and it also has the same mode of action as previously mention. In fact, the FDA warn OTC lash serum producers in 2011 about the risks of incorporating a synthetic version of a prescription drug with a known adverse effect profile from FDA studies into their formulations.

If a prospective patient knows they have had a dry eye diagnosis in the past or are at increase risk, statements from companies claiming that they "contain no active medical ingredient" like this from the FAQ for Rodan and Fields Lash Boost make it even more difficult for them to do their due diligence. The most well-known over-the-counter lash growth serums that include synthetic prostaglandin analogues are listing below:

  • Eyelash Enhancer Xlash
  • Blush Neuveau Lashes
  • Nutraluxe Revita Lash MD M2 Lash Lashes serum to activate eyelashes
  • Roth, Peter Thomas Platinum Rodan and Fields Lash Boost: the ultimate in lashes